NICU

Allergic Colitis of Infancy

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Allergic Colitis of Infancy, Cow's Milk Allergy, Milk Protein Intolerance, Milk Protein Allergy, Food Protein Induced Proctocolitis of Infancy, Cow's Milk Protein Sensitivity, Milk Protein Sensitivity, Cow’s Milk Protein Allergy, CMPA

  • See Also
  1. Food Allergy
  2. Upper Gastrointestinal Bleeding
  3. Lower Gastrointestinal Bleeding
  • Epidemiology
  1. Age: 0-10 months (usually presents 3 weeks - 3 months)
  • Pathophysiology
  1. Distal colon inflammatory reaction to Cow's Milk Protein
  2. Appears to not be IgE mediated
  3. Concomitant soy milk reaction in 30% of infants
  • Predisposing factors
  1. Early introduction of cow's milk
    1. Especially after Gastroenteritis
  • Symptoms
  1. Loose Bowel Movements
  2. Blood and mucus streaked stools
  3. Otherwise healthy infant with normal growth
  4. Vomiting (possible Hematemesis)
  5. Hives
  • Differential Diagnosis
  1. Swallowed maternal blood (during delivery, or from cracked nipples)
    1. Most common cause of infants with blood in stool
  2. Infectious Colitis causing bloody stool (Salmonella, Shigella)
  3. Enterocolitis due to Necrotizing Enterocolitis
  4. Anal Fissure
  5. Hirschsprung's Disease
  • Labs
  1. Stool studies
    1. Leukocytes
    2. Stool Guaiac
    3. Stool Culture
    4. Wright's Stain for Eosinophils
  2. Complete Blood Count with differential
    1. Eosinophilia
  3. RAST testing not useful
  • Management
  1. Nursing Mothers
    1. Avoid milk and possibly soy products in maternal diet
  2. Formula fed
    1. May trial on Soy Formula first (previously not recommended)
    2. Casein Hydrolysate formula (e.g. Nutramigen)
    3. Elemental formula (Neocate) for refractory cases
  3. Re-challenge with cow's milk at 1 year
  • Prognosis
  1. Infants outgrow in 95% cases by age 1 year
  • References
  1. Mason and Woods in Herbert (2019) EM:Rap 19(2): 7-8