Virus

Filoviridae

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Filoviridae, Filovirus, Filoviridae Infection, Filovirus Infection

  • See Also
  1. Viral Hemorrhagic Fever
  2. Virus
  • Pathophysiology
  1. Filoviridae are a family of viruses causing Viral Hemorrhagic Fever
    1. Filoviridae cause Viral Hemorrhagic Fever in Sub-Sahara Africa with high mortality (50-80%)
    2. Filoviridae are Enveloped, helical single stranded RNA Viruses
    3. Filoviridae infect pigs, bats and primates (including humans)
    4. Filamentous shaped viruses
      1. Name derived from the latin "Filo, meaning filament
  2. Transmission
    1. Direct contact with body secretions (blood, vomit, urine, stool, semen)
  3. Filoviridae are Anti-Message Sense RNA Viruses (Negative Stranded, -ssRNA)
    1. Anti-Message sense RNA (-ssRNA) need to first be transcribed into +ssRNA
    2. RNA dependent RNA Polymerase (RNA replicase, RdRp)
      1. RdRp is an enzyme carried by the -ssRNA virus within its capsid
      2. RdRp transcribes -ssRNA into +ssRNA within the host cell
    3. Translation follows +ssRNA transcription from -ssRNA (by RdRp)
      1. As with mRNA, +ssRNA translated by host ribosomes into Protein
  • Types
  1. Ebola Virus
  2. Marburg Virus
  • Resources
  1. Filoviruses (StatPearls)
    1. https://www.ncbi.nlm.nih.gov/books/NBK544258/
  • References
  1. Gladwin, Trattler and Mahan (2014) Clinical Microbiology, Medmaster, Fl, p. 305-13