Peds

Hypospadias

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Hypospadias

  • Epidemiology
  1. Incidence: 1 in 150 per male births (among most common congenital anomalies in males)
  1. Father with Hypospadias: 8% risk
  2. Brother with Hypospadias: 14% risk
  • Pathophysiology
  1. Congenital defect of Urethral meatus development
  2. Urethral folds incompletely fuse
  3. Ectopic Urethral meatus between glans and perineum (ventral side of penis)
  • Associated Conditions
  1. Identified on exam
    1. Undescended Testicle (10% association)
    2. Inguinal Hernia
    3. Hydrocele
    4. Chordee (ventral penile curvature)
  2. Identified on Ultrasound
    1. Vesicoureteral Reflux
    2. Ureteropelvic junction obstruction
    3. Horseshoe Kidney (or pelvic Kidney)
    4. Crossed renal ectopia
    5. Renal agenisis
  • Classification
  1. Anterior (Distal penis and glans): 50% of cases
  2. Middle (Midshaft of penis): 30% of cases
  3. Posterior (Scrotum, Perineum): 20% of cases
  • Management
  1. Avoid Circumcision (foreskin needed for repair)
  2. Consult Pediatric urology
    1. Initial Consultation at time of diagnosis
    2. Referral at age 3 to 4 months
  3. Surgical repair at 6 to 12 months of age
    1. Distal Hypospadias (most common)
      1. Typically repaired in a single surgery (curvature repaired at same time)
      2. Urethral catheter is typically in place for 1 week following surgery
      3. Few complications
    2. Proximal Hypospadias
      1. Evaluate for disorder of Sexual Development if Undescended Testicle also present
      2. Often requires 2 procedures for repair (esp. if severe curvature)
      3. Second surgery if needed is performed at 6 months
      4. Uses foreskin for repair graft (if second procedure needed)
  • Complications
  • Surgical Repair
  1. Complications 5-15% (highest for posterior Hypospadias)
  2. Urethrocutaneous fistula or Urethral Diverticulum
  3. Meatal stenosis
  4. Wound Infection, Hematoma or dehiscence
  • Complications
  • Utreated
  1. Urine stream deformity
  2. Sexual Dysfunction associated with curvature
  3. Infertility associated with proximal Urethral meatus
  • References
  1. Behrman (2000) Nelson Pediatrics, Saunders, p. 1645-7
  2. Granberg (2024) Mayo Clinic Pediatric Days, lecture attended 1/18/2024
  3. Borer (1999) Urol Clin North Am 26(1): 15-37 [PubMed]
  4. Dunn (2026) Am Fam Physician 113(6): 587-8 [PubMed]